IL23 Protein (AA 20-189, AA 23-328) (DYKDDDDK Tag)
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- Target See all IL23 Proteins
- IL23 (Interleukin 23 (IL23))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-189, AA 23-328
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL23 protein is labelled with DYKDDDDK Tag.
- Purpose
- IL-23 (human) (rec.)
- Specificity
- Human IL-12p40 peptide (aa 23-328) is fused at the C-terminus to a 18 aa linker peptide (GSTSGSGKPGSGEGSTKG) and to the IL-23p19 peptide (aa 20-189) and fused at the N-terminus to a FLAG®-tag.
- Characteristics
- Protein. Human IL-12p40 peptide (aa 23-328) is fused at the C-terminus to a 18 aa linker peptide (GSTSGSGKPGSGEGSTKG) and to the IL-23p19 peptide (aa 20-189) and fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: <0.06EU/μg purified protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >90 % (SDS-PAGE). Interleukin-23 (IL-23) is a heterodimeric cytokine and a member of the IL-12 family involved in innate and adaptive immunity. It is composed of the IL-12 p40 chain covalently linked to p19, a chain related to the IL-12 p35 subunit. IL-23 signals through the IL-23 receptor complex, which is composed of the IL-12Rbeta1 chain and a gp130-like chain, IL-23R. Triggering of the IL-23 receptor complex leads to the activation of Tyk2, Jak2 and STAT1, 3 and 4. IL-23 induces IFN-gamma production, Th1 cell differentiation, and activation of the antigen-presenting functions of dendritic cells. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and important for tumorigenesis.
- Purity
- >90 % (SDS-PAGE)
- Endotoxin Level
- <0.06EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product IL23 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- IL23 (Interleukin 23 (IL23))
- Alternative Name
- IL-23 (IL23 Products)
- Synonyms
- IL-23 Protein, p19 Protein, SGRF Protein, il23p19 Protein, interleukin 23, alpha subunit p19 Protein, interleukin 23 subunit alpha Protein, Il23a Protein, IL23A Protein
- Background
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Alternate Names/Synonyms: Interleukin-23
Product Description: Interleukin-23 (IL-23) is a heterodimeric cytokine and a member of the IL-12 family involved in innate and adaptive immunity. It is composed of the IL-12 p40 chain covalently linked to p19, a chain related to the IL-12 p35 subunit. IL-23 signals through the IL-23 receptor complex, which is composed of the IL-12Rbeta1 chain and a gp130-like chain, IL-23R. Triggering of the IL-23 receptor complex leads to the activation of Tyk2, Jak2 and STAT1, 3 and 4. IL-23 induces IFN-gamma production, Th1 cell differentiation, and activation of the antigen-presenting functions of dendritic cells. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and important for tumorigenesis.
- Molecular Weight
- ~70kDa (SDS-PAGE)
- UniProt
- Q9NPF7, P29460
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