TCP1 alpha/CCTA Protein (full length)

Catalog No. ABIN624091

Product Details

Target: TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))

Protein Type: Recombinant

Protein Characteristics: full length

Origin: Human

Host: Please inquire

Application: Western Blotting (WB), ELISA, Blocking Antibody (Inhibition)

Characteristics: Recombinant Human p63

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: p63 in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.

Storage: -20 °C

Target Details

Target: TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))

Alternative Name: p63 (TCP1 Products)

Synonyms: CCT-alpha Protein, CCT1 Protein, CCTa Protein, D6S230E Protein, TCP-1-alpha Protein, AI528772 Protein, CCT Protein, Cct1 Protein, Ccta Protein, TRic Protein, Tcp-1 Protein, Tp63 Protein, c-cpn Protein, p63 Protein, TRiC Protein, CCTalpha Protein, BEST:GH05123 Protein, CG5374 Protein, Dmel\\CG5374 Protein, T-cpl Protein, TCP-1alpha Protein, TCPA_DROME Protein, Tcp1 Protein, Tcp1-alpha Protein, gh05123 Protein, cct-alpha Protein, ccta Protein, tcp1 Protein, tcp1-a Protein, tcp1a Protein, tcp1alpha Protein, CHUNP6875 Protein, fa13h08 Protein, wu:fa13h08 Protein, wu:fc95g06 Protein, t-complex 1 Protein, T-complex protein 1 subunit alpha Protein, t-complex protein 1 Protein, Tcp1-like Protein, t-complex 1 S homeolog Protein, TCP1 Protein, cct-1 Protein, Tcp1 Protein, T-cp1 Protein, tcp1.S Protein, tcp1 Protein

Background: P63 Human Recombinant (aa 319-410) expressed in E.coli, shows a 36 kDa band on SDS-PAGE. The p63 is purified by proprietary chromatographic techniques. Introduction: The p63 gene, a homologue of the tumor-suppressor p53, is highly expressed in the basal or progenitor layers of many epithelial tissues. The p63 gene belongs to p53 family of transcription factors. P63 shows remarkable structural similarity to p53 and to the related p73 gene. Alternative splicing and using alternative promoters results in multiple transcript variants encoding different proteins. Numerous transcripts encoding different proteins were found but the biological validity and the full-length nature of these variants have not been determined. Unlike p53, the p63 gene encodes multiple isotypes with remarkably divergent abilities to transactivate p53 reporter genes and induce apoptosis. p63 is associated with ectrodactyly-ectodermal dysplasia-cleft syndrome and Hay-Wells syndrome. p63 immunostaining is useful for differentiating prostatic adenocarcinoma (the most common type of prostate cancer) and benign prostatic tissue, normal prostatic glands stain with p63 (since they have basal cells), while the malignant glands in prostatic adenocarcinoma (which lacks these cells) do not. Synonyms: Tumor protein 63, p63, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p51, p40, Keratinocyte transcription factor KET, Chronic ulcerative stomatitis protein, CUSP, KET, P73H, TP73L, AIS, LMS, NBP, RHS, EEC3, OFC8, SHFM4, TP53L, p53CP, TP53CP, B(p51A), B(p51B).