HSC70 Interacting Protein HIP Protein (AA 12-369)

Catalog No. ABIN620956

Product Details

Target: HSC70 Interacting Protein HIP (ST13) (Suppression of Tumorigenicity 13 (ST13))

Protein Type: Recombinant

Protein Characteristics: AA 12-369

Origin: Human

Host: Please inquire

Sequence: MDPRKVNELR AFVKMCKQDP SVLHTEEMRF LREWVESMGG KVPPATQKAK SEENTKEEKP DSKKVEEDLK ADEPSSEESD LEIDKEGVIE PDTDAPQEMG DENAEITEEM MDQANDKKVA AIEALNDGEL QKAIDLFTDA IKLNPRLAIL YAKRASVFVK LQKPNAAIRD CDRAIEINPD SAQPYKWRGK AHRLLGHWEE AAHDLALACK LDYDEDASAM LKEVQPRAQK IAEHRRKYER KREEREIKER IERVKKAREE HERAQREEEA RRQSGAQYGS FPGGFPGGMP GNFPGGMPGM GGGMPGMAGM PGLNEILSDP EVLAAMQDPE VMVAFQDVAQ NPANMSKYQS NPKVMNLISK LSAKFGGQA

Characteristics: Recombinant Human HSP70 Interacting Protein

Purity: > 90.0 % as determined by SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The ST13 protein solution contains 20mM Tris-HCl, pH-8 1mM DTT, 0.1M NaCl and 10% Glycerol.

Storage: 4 °C

Target Details

Target: HSC70 Interacting Protein HIP (ST13) (Suppression of Tumorigenicity 13 (ST13))

Alternative Name: HSP70 Interacting Protein (ST13 Products)

Synonyms: CG32789 Protein, Dmel\\CG32789 Protein, anon-EST:fe1A9 Protein, 1110007I03Rik Protein, 3110002K08Rik Protein, AW555194 Protein, HIP Protein, HOP Protein, HSPABP Protein, HSPABP1 Protein, PRO0786 Protein, SNC6 Protein, p48 Protein, AAG2 Protein, FAM10A1 Protein, FAM10A4 Protein, P48 Protein, Hsc/Hsp70-interacting protein Protein, suppression of tumorigenicity 13 Protein, ST13, Hsp70 interacting protein Protein, suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) Protein, HIP Protein, St13 Protein, ST13 Protein

Background: Recombinant Human ST13 produced in E.Coli is a single,non-glycosylated polypeptide chain containing 369 amino acids (12-369 a.a.) and having a molecular mass of 41.3 kDa. ST13 human recombinant is purified by conventional chromatogarpahy techniques. Introduction: ST13 is an adaptor protein (co-chaperone) that mediates the association of HSP70 and HSP90 and appears in early receptor complexes. ST13 plays a role in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of ST13 is downregulated in colorectal carcinoma tissue signifying that is candidate tumor suppressor gene. Through common binding to both Hsp70 and Hsp90, ST13 functions as an adaptor that can integrate Hsp70 and Hsp90 interactions. The expression of ST13 decreases in colorectal cancer tissue compared with that in adjacent normal tissue. ST13 is mostly expressed in colorectal epithelia and adenocarcinoma cells. ST13 functions to promote the efficiency of glucocorticoid receptor maturation in cells. The expression levels of the ST13 gene were significantly decreased in primary tumors compared with adjacent mucosa. Synonyms: AAG2, SNC6, HSPABP, FAM10A1, FAM10A4, HSPABP1, ST-13, Hsc70-interacting protein, Suppression of tumorigenicity protein 13, Putative tumor suppressor ST13, Protein FAM10A1, Progesterone receptor-associated p48 protein, Renal carcinoma antigen NY-REN-33, ST13, HIP, HOP, P48, PRO0786, FLJ27260, MGC129952.