alpha-Thrombin Protein

Catalog No. ABIN620925

Product Details

Target: alpha-Thrombin

Protein Type: Recombinant

Origin: Human

Source: Human

Characteristics: Human Thrombin

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The Factor-IIa contains 50mM sodium Citrate, 0.2M NaCl and 0.1% PEG-8000 pH 6.5.

Storage: -20 °C

Target Details

Target: alpha-Thrombin

Alternative Name: Thrombin (alpha-Thrombin Products)

Synonyms: PT Protein, RPRGL2 Protein, THPH1 Protein, coagulation factor II, thrombin Protein, F2 Protein

Background: Introduction: Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.