PTPN11 Protein (AA 1-460) (His tag)
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- Target See all PTPN11 Proteins
- PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-460
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Origin
- Human
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This PTPN11 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- ADPMTSRRWF HPNITGVEAE NLLLTRGVDG SFLARPSKSN PGDFTLSVRR NGAVTHIKIQ NTGDYYDLYG GEKFATLAEL VQYYMEHHGQ LKEKNGDVIE LKYPLNCADP TSERWFHGHL SGKEAEKLLT EKGKHGSFLV RESQSHPGDF VLSVRTGDDK GESNDGKSKV THVMIRCQEL KYDVGGGERF DSLTDLVEHY KKNPMVETLG TVLQLKQPLN TTRINAAEIE SRVRELSKLA ETTDKVKQGF WEEFETLQQQ ECKLLYSRKE GQRQENKNKN RYKNILPFDH TRVVLHDGDP NEPVSDYINA NIIMPEFETK CNNSKPKKSY IATQGCLQNT VNDFWRMVFQ ENSRVIVMTT KEVERGKSKC VKYWPDEYAL KEYGVMRVRN VKESAAHDYT LRELKLSKVG QGNTERTVWQ YHFRTWPDHG VPSDPGGVLD FLEEVHHKQE SIMDAGPVVV HCRHHHHHH
- Purity
- > 90 % by SDS - PAGE
- Endotoxin Level
- < 1.0 EU per 1ug of protein (determined by LAL method)
- Top Product
- Discover our top product PTPN11 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In Phosphate Buffered Saline ( pH 7.4) containing 10 % glycerol.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
- Alternative Name
- PTPN11 (PTPN11 Products)
- Synonyms
- BPTP3 Protein, CFC Protein, NS1 Protein, PTP-1D Protein, PTP2C Protein, SH-PTP2 Protein, SH-PTP3 Protein, SHP2 Protein, 2700084A17Rik Protein, AW536184 Protein, PTP1D Protein, SAP-2 Protein, SHP-2 Protein, Shp2 Protein, Syp Protein, SYP Protein, bptp3 Protein, cfc Protein, ns1 Protein, ptp-2 Protein, ptp2c Protein, ptpn11 Protein, ptpn11-a Protein, ptpn11-b Protein, shp-2 Protein, shp2 Protein, fa14b09 Protein, wu:fa14b09 Protein, wu:fi24f03 Protein, zgc:55388 Protein, zgc:63553 Protein, protein tyrosine phosphatase, non-receptor type 11 Protein, protein tyrosine phosphatase, non-receptor type 11 S homeolog Protein, protein tyrosine phosphatase, non-receptor type 11, a Protein, protein tyrosine phosphatase, non-receptor type 11, b Protein, PTPN11 Protein, Ptpn11 Protein, ptpn11.S Protein, ptpn11a Protein, ptpn11b Protein
- Target Type
- Viral Protein
- Background
- PTPN11, also known as tyrosine-protein phosphatase non-receptor type 11 isoform 2, belongs to the protein-tyrosine phosphatase (PTP) family, non-receptor class 2 subfamily. It participates in signal transduction from the cell surface to the nucleus downstream of various receptor and cytosolic protein tyrosine kinases. This protein deficient cells have poor mobility because excessive phosphorylation of FAK and other proteins interferes with the rotation of cell attachment points in the focal adhesion complex. Recombinant human PTPN11, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
- Molecular Weight
- 53.9kDa (469aa) 50-70kDa (SDS-PAGE under reducing conditions)
- NCBI Accession
- NP_542168
- UniProt
- Q06124
- Pathways
- JAK-STAT Signaling, RTK Signaling, TCR Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, Warburg Effect
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