DYRK1A Protein (AA 159-479) (His tag)
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- Target See all DYRK1A Proteins
- DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 159-479
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This DYRK1A protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH RSYEIDSLIG KGSFGQVVKA YDRVEQEWVA IKIIKNKKAF LNQAQIEVRL LELMNKHDTE MKYYIVHLKR HFMFRNHLCL VFEMLSYNLY DLLRNTNFRG VSLNLTRKFA QQMCTALLFL ATPELSIIHC DLKPENILLC NPKRSAIKIV DFGSSCQLGQ RIYQYIQSRF YRSPEVLLGM PYDLAIDMWS LGCILVEMHT GEPLFSGANE VDQMNKIVEV LGIPPAHILD QAPKARKFFE KLPDGTWSLK KTKDGKREYK PPGTRKLHNI LGVETGGPGG RRAGESGHTV ADYLKFKDLI LRMLDYDPKT RIQPYYALQH SFF
- Purity
- > 80 % by SDS - PAGE
- Top Product
- Discover our top product DYRK1A Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Denatured
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.0 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 10 % glycerol, 0.4M urea
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
- Alternative Name
- DYRK1A (DYRK1A Products)
- Synonyms
- DYRK1A Protein, dyrk Protein, dyrk1 Protein, hp86 Protein, mnb Protein, mnbh Protein, DYRK Protein, DYRK1 Protein, HP86 Protein, MNB Protein, MNBH Protein, MRD7 Protein, 2310043O08Rik Protein, D16Ertd272e Protein, D16Ertd493e Protein, Dyrk Protein, ENSMUSG00000074897 Protein, Gm10783 Protein, Mnbh Protein, Mp86 Protein, mmb Protein, PSK47 Protein, dual specificity tyrosine phosphorylation regulated kinase 1A Protein, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Protein, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a Protein, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A S homeolog Protein, DYRK1A Protein, dyrk1a Protein, Dyrk1a Protein, dyrk1a.S Protein
- Background
- DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidin6e repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. Recombinant human DYRK1A protein, fused to His-tag at N-terminus, was expressed in E.coli .
- Molecular Weight
- 39.4 kDa (343 aa)
- NCBI Accession
- NP_036923
- UniProt
- Q63470
- Pathways
- Mitotic G1-G1/S Phases
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