EXOSC8 Protein (AA 1-276) (His tag)

Catalog No. ABIN5853637

Product Details

Target: EXOSC8 (Exosome Component 8 (EXOSC8))

Protein Type: Recombinant

Protein Characteristics: AA 1-276

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This EXOSC8 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAAGFKT VEPLEYYRRF LKENCRPDGR ELGEFRTTTV NIGSISTADG SALVKLGNTT VICGVKAEFA APSTDAPDKG YVVPNVDLPP LCSSRFRSGP PGEEAQVASQ FIADVIENSQ IIQKEDLCIS PGKLVWVLYC DLICLDYDGN ILDACTFALL AALKNVQLPE VTINEETALA EVNLKKKSYL NIRTHPVATS FAVFDDTLLI VDPTGEEEHL ATGTLTIVMD EEGKLCCLHK PGGSGLTGAK LQDCMSRAVT RHKEVKKLMD EVIKSMKPK

Purity: > 90 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. 20  mM Tris-HCl buffer (  pH 8.0) containing 50 % glycerol 0.2M NaCl,1  mM DTT

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: EXOSC8 (Exosome Component 8 (EXOSC8))

Alternative Name: EXOSC8 (EXOSC8 Products)

Synonyms: wu:fb79a10 Protein, zgc:110381 Protein, MGC52847 Protein, MGC132146 Protein, EXOSC8 Protein, MGC79733 Protein, CIP3 Protein, EAP2 Protein, OIP2 Protein, RP11-421P11.3 Protein, RRP43 Protein, Rrp43p Protein, bA421P11.3 Protein, p9 Protein, 2310032N20Rik Protein, mKIAA4013 Protein, exosome component 8 Protein, exosome component 8 S homeolog Protein, Exosc8 Protein, exosc8 Protein, exosc8.S Protein, EXOSC8 Protein

Background: EXOSC8, also known as exosome component 8 and transcription factor 4, is a part of the exosome complex. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing Au-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC8 binds to ARE-containing RNAs. Recombinant human EXOSC8 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Molecular Weight: 32.4 kDa(299aa) confirmed by MALDI-TOF

NCBI Accession: NP_852480

UniProt: Q96B26

Pathways: SARS-CoV-2 Protein Interactome