MCM7 Protein (AA 1-414) (His tag)
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- Target See all MCM7 Proteins
- MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-414
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MCM7 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMVVATYT CDQCGAETYQ PIQSPTFMPL IMCPSQECQT NRSGGRLYLQ TRGSRFIKFQ EMKMQEHSDQ VPVGNIPRSI TVLVEGENTR IAQPGDHVSV TGIFLPILRT GFRQVVQGLL SETYLEAHRI VKMNKSEDDE SGAGELTREE LRQIAEEDFY EKLAASIAPE IYGHEDVKKA LLLLLVGGVD QSPRGMKIRG NINICLMGDP GVAKSQLLSY IDRLAPRSQY TTGRGSSGVG LTAAVLRDSV SGELTLEGGA LVLADQGVCC IDEFDKMAEA DRTAIHEVME QQTISIAKAG ILTTLNARCS ILAAANPAYG RYNPRRSLEQ NIQLPAALLS RFDLLWLIQD RPDRDNDLRL AQHITYVHQH SRQPPSQFEP LDMKLMRRYI AMCREKQPMV PESLADYITA AYVEMRR
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product MCM7 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Denatured
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.4M uREA, 10 % glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))
- Alternative Name
- MCM7 (MCM7 Products)
- Synonyms
- CDC47 Protein, MCM2 Protein, P1.1-MCM3 Protein, P1CDC47 Protein, P85MCM Protein, PNAS146 Protein, MCM7 Protein, AI747533 Protein, Mcmd7 Protein, mCDC47 Protein, chunp6911 Protein, nyz175 Protein, sr:nyz175 Protein, cdc47 Protein, cdc47-2 Protein, mcm7 Protein, xmcm7 Protein, CG4978 Protein, DmMCM7 Protein, DmeMCM7 Protein, Dmel\\CG4978 Protein, McM7 Protein, Mcp-PCR1 Protein, PCR1 Protein, anon-EST:Liang-1.66 Protein, clone 1.66 Protein, minichromosome maintenance complex component 7 Protein, mini-chromosome maintenance complex protein 7 Protein, minichromosome maintenance complex component 2 Protein, minichromosome maintenance complex component 7 L homeolog Protein, Minichromosome maintenance 7 Protein, minichromosome maintenance complex component 7 S homeolog Protein, MCM complex subunit Mcm7 Protein, MCM7 Protein, CDC47 Protein, Mcm7 Protein, MCM2 Protein, mcm7 Protein, mcm7.L Protein, mcm7.S Protein
- Background
- MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Recombinant human MCM7 protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 48.6kDa (437aa)
- NCBI Accession
- NP_877577
- UniProt
- P33993
- Pathways
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
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