PSTPIP1 Protein (AA 1-416) (His tag)
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- Target See all PSTPIP1 Proteins
- PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-416
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PSTPIP1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMMPQLQF KDAFWCRDFT AHTGYEVLLQ RLLDGRKMCK DMEELLRQRA QAEERYGKEL VQIARKAGGQ TEINSLRASF DSLKQQMENV GSSHIQLALT LREELRSLEE FRERQKEQRK KYEAVMDRVQ KSKLSLYKKA MESKKTYEQK CRDADDAEQA FERISANGHQ KQVEKSQNKA RQCKDSATEA ERVYRQSIAQ LEKVRAEWEQ EHRTTCEAFQ LQEFDRLTIL RNALWVHSNQ LSMQCVKDDE LYEEVRLTLE GCSIDADIDS FIQAKSTGTE PPAPVPYQNY YDREVTPLTS SPGIQPSCGM IKRFSGLLHG SPKTTSLAAS AASTETLTPT PERNEGVYTA IAVQEIQGNP ASPAQEYRAL YDYTAQNPDE LDLSAGDILE VILEGEDGWW TVERNGQRGF VPGSYLEKL
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product PSTPIP1 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.15M NaCl, 20 % glycerol, 1 mM DTT
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))
- Alternative Name
- PSTPIP1 (PSTPIP1 Products)
- Synonyms
- cd2bp1 Protein, cd2bp1l Protein, cd2bp1s Protein, h-pip Protein, papas Protein, pstpip Protein, PSTPIP1 Protein, CD2BP1 Protein, CD2BP1L Protein, CD2BP1S Protein, H-PIP Protein, PAPAS Protein, PSTPIP Protein, def-2 Protein, proline-serine-threonine phosphatase interacting protein 1 Protein, proline-serine-threonine phosphatase interacting protein 1 S homeolog Protein, proline-serine-threonine phosphatase-interacting protein 1 Protein, PSTPIP1 Protein, pstpip1.S Protein, pstpip1 Protein, Pstpip1 Protein
- Background
- PSTPIP1 binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. Recombinant human PSTPIP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 50.0kDa (439aa)
- NCBI Accession
- NP_003969
- UniProt
- O43586
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