alpha 2 Macroglobulin Protein (AA 620-750, partial) (His tag)

Catalog No. ABIN5713188

Product Details

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Protein Type: Recombinant

Protein Characteristics: AA 620-750, partial

Origin: Rat

Source: Yeast

Purification tag / Conjugate: This alpha 2 Macroglobulin protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: LIYDLLPVKD LTGFPQGADQ REEDTNGCVK QNDTYINGIL YSPVQNTNEE DMYGFLKDMG LKVFTNSNIR KPKVCERLRD NKGIPAAYHL VSQSHMDAFL ESSESPTETR RSYFPETWIW DLVVVDSAGV A

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: A2MG (A2M Products)

Synonyms: A2MD Protein, CPAMD5 Protein, FWP007 Protein, S863-7 Protein, A2MAC1 Protein, A2m1 Protein, A2maa Protein, Mam Protein, A2mp Protein, A2M Protein, LOC733429 Protein, endod Protein, cpamd5 Protein, fwp007 Protein, s863-7 Protein, a2mb Protein, endodermin Protein, Alpha-2-M Protein, alpha-2-macroglobulin Protein, pregnancy-zone protein L homeolog Protein, alpha-2-macroglobulin S homeolog Protein, pregnancy zone protein Protein, alpha-2-macroglobulin-like Protein, A2M Protein, A2m Protein, LOC477699 Protein, pzp.L Protein, AZL_c00450 Protein, LOC100349077 Protein, a2m Protein, LOC100061656 Protein, LOC100090399 Protein, a2m.S Protein, LOC100469973 Protein, LOC100595735 Protein, PZP Protein, LOC100353095 Protein, LOC101122940 Protein, LOC101801552 Protein, LOC100911545 Protein

Background: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme rains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Molecular Weight: 16.9 kDa

UniProt: P06238

Pathways: Lipid Metabolism