TMEM66 Protein (AA 195-339) (His-SUMO Tag)
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- Target See all TMEM66 Proteins
- TMEM66 (Transmembrane Protein 66 (TMEM66))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 195-339
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This TMEM66 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- SDGQYSPPPY SEYPPFSHRY QRFTNSAGPP PPGFKSEFTG PQNTGHGATS GFGSAFTGQQ GYENSGPGFW TGLGTGGILG YLFGSNRAAT PFSDSWYYPS YPPSYPGTWN RAYSPLHGGS GSYSVCSNSD TKTRTASGYG GTRRR
- Purification
- SDS-PAGE
- Purity
- > 90 %
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- TMEM66 (Transmembrane Protein 66 (TMEM66))
- Alternative Name
- SARAF (TMEM66 Products)
- Synonyms
- FOAP-7 Protein, SARAF Protein, XTP3 Protein, 1810045K07Rik Protein, tmem66 Protein, Tmem66 Protein, TMEM66 Protein, store-operated calcium entry associated regulatory factor Protein, store-operated calcium entry-associated regulatory factor Protein, store-operated calcium entry-associated regulatory factor S homeolog Protein, transmembrane protein 66 Protein, SARAF Protein, Saraf Protein, saraf Protein, saraf.S Protein, MCYG_05410 Protein, MGYG_06464 Protein, Tsp_10089 Protein
- Background
- Negative regulator of store-operated Ca2+ entry (SOCE) involved in protecting cells from Ca2+ overfilling. In response to cytosolic Ca2+ elevation after endoplasmic reticulum Ca2+ refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca2+ levels, and thus preventing the overload of the cell with excessive Ca2+ ions.
- Molecular Weight
- 31.48 kDa
- UniProt
- Q96BY9
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