CASP14 Protein (AA 153-240) (GST tag)
CASP14
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
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- Target See all CASP14 Proteins
- CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 153-240
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CASP14 protein is labelled with GST tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- KDSPQTIPTY TDALHVYSTV EGYIAYRHDQ KGSCFIQTLV DVFTKRKGHI LELLTEVTRR MAEAELVQEG KARKTNPEIQ STLRKRLY
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product CASP14 Protein
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Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14) (AA 133-242) protein (GST tag)
CASP14 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))
- Alternative Name
- CASPE (CASP14 Products)
- Synonyms
- CASP14 Protein, MICE Protein, mini-ICE Protein, caspase 14, apoptosis-related cysteine peptidase Protein, caspase 14 Protein, caspase-14-like Protein, caspase-14 Protein, CASP14 Protein, Casp14 Protein, LOC485601 Protein, LOC780455 Protein
- Background
- Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum . Ses to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin . In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF . Involved in processing of prosaposin in the epidermis . May be involved in retinal pigment epithelium cell barrier function . Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD .
- Molecular Weight
- 37.6 kDa
- UniProt
- P31944
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