IL36A/IL1F6 Protein
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- Target See all IL36A/IL1F6 (IL1F6) Proteins
- IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Purpose
- IL-36alpha (aa 6-158) (human) (rec.) (untagged)
- Cross-Reactivity
- Human
- Characteristics
- Human IL-36alpha (aa Lys6-Phe158) is untagged.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test).
- Top Product
- Discover our top product IL1F6 Protein
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Interleukin 1 Family, Member 6 (IL1F6) (Active) protein
IL1F6 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by reducing SDS-PAGE. Active
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) protein (His tag)IL1F6 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-160) protein (His tag)IL1F6 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Interleukin 1 Family, Member 6 (IL1F6) (AA 1-158) protein (GST tag)IL1F6 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Interleukin 1 Family, Member 6 (IL1F6) protein (Myc-DYKDDDDK Tag)IL1F6 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- 0.1 mg/mL
- Buffer
- Contains PBS.
- Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- Expiry Date
- 6 months
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- Target
- IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
- Alternative Name
- IL-36alpha (IL1F6 Products)
- Background
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Interleukin-36alpha, Interleukin-1 Family Member 6, IL-1F6, FIL1epsilon, Interleukin-1epsilon, Interleukin-1 Homolog 1, IL-1H1
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. Recently a novel role for IL-36alpha in the pathogenesis of intestinal inflammation has been reported.
- Molecular Weight
- ~17kDa
- UniProt
- Q9UHA7
- Pathways
- Cancer Immune Checkpoints
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