FOLR1 Protein (AA 25-232) (His tag)
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- Target See all FOLR1 Proteins
- FOLR1 (Folate Receptor 1 (Adult) (FOLR1))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 25-232
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FOLR1 protein is labelled with His tag.
- Sequence
- AA 25-232
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.2 kDa. The protein migrates as 35 kDa and 37 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product FOLR1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris and Glycine, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- FOLR1 (Folate Receptor 1 (Adult) (FOLR1))
- Alternative Name
- FOLR1 (FOLR1 Products)
- Synonyms
- FBP Protein, FOLR Protein, fbp Protein, folr Protein, folr1 Protein, FBP1 Protein, Folbp-1 Protein, Folbp1 Protein, Fbp1 Protein, FOLR1 Protein, Folr1 Protein, folate receptor 1 Protein, folate receptor 1 (adult) Protein, folate receptor 1 (adult) L homeolog Protein, zgc:165502 Protein, Folate receptor alpha Protein, folate receptor alpha Protein, FOLR1 Protein, folr1 Protein, folr1.L Protein, zgc:165502 Protein, Folr1 Protein, LOC100066084 Protein, LOC100725439 Protein
- Background
- Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.
- Molecular Weight
- 26.2 kDa
- NCBI Accession
- NP_032060
- Pathways
- Dicarboxylic Acid Transport
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