FLT4 Protein (AA 25-776) (Fc Tag)
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- Target See all FLT4 Proteins
- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 25-776
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FLT4 protein is labelled with Fc Tag.
- Sequence
- AA 25-776
- Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 111.2 kDa. As a result of glycosylation, the protein migrates as 140-160 kDa under reducing (R) condition, and 280-320 kDa under non-reducing (NR) condition (SDS-PAGE).
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product FLT4 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
- Alternative Name
- VEGF R3 (FLT4 Products)
- Synonyms
- FLT41 Protein, LMPH1A Protein, PCL Protein, VEGFR3 Protein, AI323512 Protein, Chy Protein, Flt-4 Protein, VEGFR-3 Protein, Vegfr3 Protein, cb1059 Protein, fms related tyrosine kinase 4 Protein, FMS-like tyrosine kinase 4 Protein, fms-related tyrosine kinase 4 Protein, FLT4 Protein, Flt4 Protein, flt4 Protein
- Background
- Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.
- Molecular Weight
- 111.2 kDa
- NCBI Accession
- NP_002011
- Pathways
- RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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