Pleiotrophin Protein (PTN)
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- Target See all Pleiotrophin (PTN) Proteins
- Pleiotrophin (PTN)
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- Functional Studies (Func)
- Sequence
- GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD
- Characteristics
- Biological Activity: Fully biologically active when compared to standard. The biological activity was measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons, when neurons were plated on 96 well culture plates that had been pre-coated wi
- Purity
- >96 % as determined by SDS-PAGE and HPLC.
- Sterility
- 0.2 μm filtered
- Top Product
- Discover our top product PTN Protein
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Pleiotrophin (PTN) (AA 33-168) protein (Fc Tag)
PTN Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Pleiotrophin (PTN) protein (His tag)PTN Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Pleiotrophin (PTN) (AA 33-168) protein (Fc Tag)PTN Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
Pleiotrophin (PTN) (AA 1-168) protein (GST tag)PTN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Pleiotrophin (PTN) (Active) proteinPTN Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- Pleiotrophin (PTN)
- Alternative Name
- PTN (PTN Products)
- Synonyms
- zHBNF Protein, zgc:111787 Protein, harp Protein, hbnf Protein, X-PTF Protein, hbgf8 Protein, negf1 Protein, ptn Protein, PTN Protein, HARP Protein, HBGF8 Protein, HBNF Protein, NEGF1 Protein, PTN-A Protein, HB-GAM Protein, HBBM Protein, HBGF-8 Protein, OSF-1 Protein, HBBN Protein, OSF Protein, Osf-1 Protein, Osf1 Protein, Hbnf Protein, pleiotrophin Protein, pleiotrophin L homeolog Protein, ptn Protein, PTN Protein, ptn.L Protein, Ptn Protein
- Background
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Relevance: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:1768439}.
Synonyms: PTN, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule - Molecular Weight
- 15.3 kDa
- UniProt
- P21246
- Pathways
- RTK Signaling
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