Profilin Protein (PFN) (AA 1-163)
PFN
Origin: Mouse
Host: Escherichia coli (E. coli)
Recombinant
>95 % (SDS-PAGE)
SDS
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- Target See all Profilin (PFN) Proteins
- Profilin (PFN)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-163
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Cross-Reactivity
- Mouse (Murine)
- Characteristics
- Recombinant profilin (Toxoplasma gondii) (aa 1-163).
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 100 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- Profilin (PFN)
- Alternative Name
- Profilin (PFN Products)
- Synonyms
- LOC406154 Protein, GB13380 Protein, profilin Protein, PFN Protein, PRF Protein
- Background
- TLR11, an innate sensor for profilin (Toxoplasma gondii), is an intracellular receptor that resides in the endoplasmic reticulum. The 12 membrane-spanning endoplasmic reticulum-resident protein UNC93B1 interacts directly with TLR11 and regulates the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12, a previously uncharacterized TLR, also recognizes profilin from Toxoplasma gondii. TLR12 is sufficient for recognition of profilin by plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both required in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection.
- Molecular Weight
- ~20kDa (SDS-PAGE)
- UniProt
- Q58NA1
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