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AADAT Protein (His tag)

AADAT Origin: Human Host: Escherichia coli (E. coli) Recombinant >97 % (SDS-PAGE) SDS
Catalog No. ABIN2745733
  • Target See all AADAT Proteins
    AADAT (Aminoadipate Aminotransferase (AADAT))
    Protein Type
    Recombinant
    Origin
    • 6
    • 1
    • 1
    • 1
    Human
    Source
    • 3
    • 2
    • 2
    • 2
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This AADAT protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Cross-Reactivity
    Human
    Characteristics
    Human full-length KAT II is fused at the N-terminus to a His-tag.
    Purity
    >97 % (SDS-PAGE)
    Top Product
    Discover our top product AADAT Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In 50 mM phosphate buffer pH 8.0, containing 50 mM sodium chloride and 40μM pyridoxal 5'-phosphate (PLP).
    Storage
    -20 °C,-80 °C
    Storage Comment
    Short Term Storage: -20°C
    Long Term Storage: -80°C
    Stable for at least 6 months after receipt when stored at -80°C.
    Expiry Date
    6 months
  • Target
    AADAT (Aminoadipate Aminotransferase (AADAT))
    Alternative Name
    Kynurenine Aminotransferase II (AADAT Products)
    Synonyms
    KAT2 Protein, KATII Protein, AI875679 Protein, Aadt Protein, Kat2 Protein, mKat-2 Protein, MGC80030 Protein, kat2 Protein, katii Protein, aminoadipate aminotransferase Protein, aminoadipate aminotransferase S homeolog Protein, AADAT Protein, Aadat Protein, aadat.S Protein, aadat Protein
    Background
    Kynurenine aminotransferases (KATs) are pyridoxal-5'-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.
    Molecular Weight
    ~49.8kDa
    NCBI Accession
    NP_872603
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