AADAT Protein (His tag)
-
- Target See all AADAT Proteins
- AADAT (Aminoadipate Aminotransferase (AADAT))
- Protein Type
- Recombinant
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This AADAT protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Cross-Reactivity
- Human
- Characteristics
- Human full-length KAT II is fused at the N-terminus to a His-tag.
- Purity
- >97 % (SDS-PAGE)
- Top Product
- Discover our top product AADAT Protein
-
Aminoadipate Aminotransferase (AADAT) (AA 1-429) protein (GST tag)
AADAT Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Aminoadipate Aminotransferase (AADAT) (AA 326-425) protein (GST tag)AADAT Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Aminoadipate Aminotransferase (AADAT) (Transcript Variant 1) (Active) protein (Myc-DYKDDDDK Tag)AADAT Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD, Func, PI Active
Aminoadipate Aminotransferase (AADAT) (AA 30-425) protein (His-SUMO Tag)AADAT Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Aminoadipate Aminotransferase (AADAT) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)AADAT Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- In 50 mM phosphate buffer pH 8.0, containing 50 mM sodium chloride and 40μM pyridoxal 5'-phosphate (PLP).
- Storage
- -20 °C,-80 °C
- Storage Comment
-
Short Term Storage: -20°C
Long Term Storage: -80°C
Stable for at least 6 months after receipt when stored at -80°C. - Expiry Date
- 6 months
-
- Target
- AADAT (Aminoadipate Aminotransferase (AADAT))
- Alternative Name
- Kynurenine Aminotransferase II (AADAT Products)
- Synonyms
- KAT2 Protein, KATII Protein, AI875679 Protein, Aadt Protein, Kat2 Protein, mKat-2 Protein, MGC80030 Protein, kat2 Protein, katii Protein, aminoadipate aminotransferase Protein, aminoadipate aminotransferase S homeolog Protein, AADAT Protein, Aadat Protein, aadat.S Protein, aadat Protein
- Background
- Kynurenine aminotransferases (KATs) are pyridoxal-5'-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.
- Molecular Weight
- ~49.8kDa
- NCBI Accession
- NP_872603
-
