MAP3K7 Protein (Transcript Variant A) (Myc-DYKDDDDK Tag)
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- Target See all MAP3K7 Proteins
- MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant A
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This MAP3K7 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human TAK1 / MAP3K7 (transcript variant A) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product MAP3K7 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))
- Alternative Name
- Tak1,map3k7 (MAP3K7 Products)
- Synonyms
- si:ch211-225h9.1 Protein, zgc:110612 Protein, Tak1 Protein, MEKK7 Protein, TAK1 Protein, TGF1a Protein, B430101B05 Protein, C87327 Protein, mitogen-activated protein kinase kinase kinase 7 Protein, mitogen activated protein kinase kinase kinase 7 Protein, map3k7 Protein, Map3k7 Protein, MAP3K7 Protein
- Background
- The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2 this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
- Molecular Weight
- 64 kDa
- NCBI Accession
- NP_003179
- Pathways
- NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway
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