SHC1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
-
- Target See all SHC1 Proteins
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 2
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SHC1 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
-
- Recombinant human SHC1 / SHC (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product SHC1 Protein
-
-
- Application Notes
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
-
The tag is located at the C-terminal.
- Restrictions
- For Research Use only
-
- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- Target
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
- Alternative Name
- Shc1,shc (SHC1 Products)
- Synonyms
- SHC1 Protein, SHC Protein, SHCA Protein, P66shc Protein, si:dkey-246i14.4 Protein, wu:fc10h03 Protein, shc Protein, p66shc Protein, Shc Protein, ShcA Protein, p66 Protein, SHC adaptor protein 1 Protein, Shc1p Protein, squalene--hopene cyclase Protein, SHC (Src homology 2 domain containing) transforming protein 1 Protein, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog Protein, src homology 2 domain-containing transforming protein C1 Protein, SHC1 Protein, shc1 Protein, Shc1 Protein, shc1.L Protein
- Background
- This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
- 51.5 kDa
- NCBI Accession
- NP_003020
- Pathways
- RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
-