CRADD Protein (Myc-DYKDDDDK Tag)
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- Target See all CRADD Proteins
- CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CRADD protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human RAIDD protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CRADD Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
- Alternative Name
- Raidd (CRADD Products)
- Synonyms
- cradd Protein, MGC89035 Protein, zgc:101717 Protein, CRADD Protein, DKFZp468A2219 Protein, LOC100226369 Protein, raidd Protein, MGC78788 Protein, MRT34 Protein, RAIDD Protein, CASP2 and RIPK1 domain containing adaptor with death domain Protein, CASP2 and RIPK1 domain containing adaptor with death, gene 1 Protein, CASP2 and RIPK1 domain containing adaptor with death, gene 2 S homeolog Protein, CRADD Protein, cradd.1 Protein, cradd Protein, cradd.2.S Protein, Cradd Protein
- Background
- This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.
- Molecular Weight
- 22.6 kDa
- NCBI Accession
- NP_003796
- Pathways
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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