PSMB8 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Target See all PSMB8 Proteins
- PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PSMB8 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human PSMB8 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product PSMB8 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))
- Alternative Name
- Psmb8 (PSMB8 Products)
- Synonyms
- ALDD Protein, D6S216 Protein, D6S216E Protein, JMP Protein, LMP7 Protein, NKJO Protein, PSMB5i Protein, RING10 Protein, ATP6V0D2 Protein, lmp7 Protein, prosome Protein, macropain Protein, Lmp-7 Protein, Lmp7 Protein, Ring10 Protein, proteasome subunit beta 8 Protein, proteasome subunit beta 8A Protein, proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Protein, PSMB8 Protein, psmb8a Protein, Psmb8 Protein
- Background
- The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified both isoforms are processed to yield the same mature subunit.
- Molecular Weight
- 29.6 kDa
- NCBI Accession
- NP_004150
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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