PANK2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Target See all PANK2 Proteins
- PANK2 (Pantothenate Kinase 2 (PANK2))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PANK2 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human PANK2 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product PANK2 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- PANK2 (Pantothenate Kinase 2 (PANK2))
- Alternative Name
- Pank2 (PANK2 Products)
- Synonyms
- ATPANK2 Protein, F10M6.180 Protein, F10M6_180 Protein, pantothenate kinase 2 Protein, PANK2 Protein, C20orf48 Protein, HARP Protein, HSS Protein, NBIA1 Protein, PKAN Protein, 4933409I19Rik Protein, AI642621 Protein, pantothenate kinase 2 Protein, pantothenate kinase 2, mitochondrial Protein, ribonuclease A family member 11 (inactive) Protein, PANK2 Protein, Tsp_01576 Protein, LOC100539295 Protein, Pank2 Protein, RNASE11 Protein
- Background
- This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.
- Molecular Weight
- 59.1 kDa
- NCBI Accession
- NP_705902
- Pathways
- Ribonucleoside Biosynthetic Process
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