NUDT1 Protein (Transcript Variant 3A) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2727725

Product Details

Target: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 3A

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This NUDT1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human NUDT1 (transcript variant 3A) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Alternative Name: Nudt1 (NUDT1 Products)

Synonyms: mutT Protein, nudT1 Protein, MTH1 Protein, Mth1 Protein, 7,8-dihydro-8-oxoguanine triphosphatase Protein, nudix hydrolase 1 Protein, nudix (nucleoside diphosphate linked moiety X)-type motif 1 Protein, mth1 Protein, Tsp_07498 Protein, nudt1 Protein, 8odp Protein, NUDT1 Protein, Nudt1 Protein

Background: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Molecular Weight: 17.8 kDa

NCBI Accession: NP_945188