NACA Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
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- Target See all NACA (NACa1) Proteins
- NACA (NACa1) (Nascent Polypeptide Associated Complex alpha 1 (NACa1))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 2
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NACA protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Nascent polypeptide-associated complex alpha subunit (NACA), transcript variant 2 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product NACa1 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- NACA (NACa1) (Nascent Polypeptide Associated Complex alpha 1 (NACa1))
- Alternative Name
- Nascent Polypeptide-Associated Complex alpha Subunit (Naca) (NACa1 Products)
- Synonyms
- AL022831 Protein, AL024382 Protein, Gm1878 Protein, mKIAA0363 Protein, skNAC Protein, ik:tdsubc_2b5 Protein, nkn Protein, tdsubc_2b5 Protein, xx:tdsubc_2b5 Protein, NACA1 Protein, nascent polypeptide-associated complex alpha polypeptide Protein, nascent polypeptide-associated complex alpha subunit Protein, Naca Protein, naca Protein, NACA Protein
- Background
- This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes.
- Molecular Weight
- 23.2 kDa
- NCBI Accession
- NP_001106672
- Pathways
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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