MAP3K1 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2725396

Product Details

Target: MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This MAP3K1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human MAP3K1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1))

Alternative Name: Map3k1 (MAP3K1 Products)

Synonyms: MAP3K1 Protein, Mekk1 Protein, MAPKKK1 Protein, MEKK1 Protein, Mekk Protein, ARAKIN Protein, ATMEKK1 Protein, MAPK/ERK kinase kinase 1 Protein, MAPKKK8 Protein, T15F16.5 Protein, T15F16_5 Protein, MEKK Protein, MEKK 1 Protein, SRXY6 Protein, mitogen-activated protein kinase kinase kinase 1 Protein, mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase Protein, MAPK/ERK kinase kinase 1 Protein, MAP3K1 Protein, map3k1 Protein, Map3k1 Protein, MEKK1 Protein

Background: The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.

Molecular Weight: 164.3 kDa

NCBI Accession: NP_005912

Pathways: MAPK Signaling, Interferon-gamma Pathway, Caspase Cascade in Apoptosis, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Actin Filament Polymerization, Toll-Like Receptors Cascades