MAP2K3 Protein (Transcript Variant B) (Myc-DYKDDDDK Tag)
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- Target See all MAP2K3 Proteins
- MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant B
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This MAP2K3 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human MAP2K3 (transcript variant B) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product MAP2K3 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
- Alternative Name
- Map2k3 (MAP2K3 Products)
- Synonyms
- MAPKK3 Protein, MEK3 Protein, MKK3 Protein, PRKMK3 Protein, SAPKK-2 Protein, SAPKK2 Protein, AW212142 Protein, Prkmk3 Protein, mMKK3b Protein, Mkk3 Protein, mitogen-activated protein kinase kinase 3 Protein, mitogen activated protein kinase kinase 3 Protein, MAP kinase activator XMEK3 Protein, MAP2K3 Protein, Map2k3 Protein, map2k3 Protein
- Background
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
- Molecular Weight
- 39.1 kDa
- NCBI Accession
- NP_659731
- Pathways
- MAPK Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2
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