MAPKSP1 Protein (Transcript Variant 1) (His tag)
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- Target See all MAPKSP1 Proteins
- MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MAPKSP1 protein is labelled with His tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human MAP2K1IP1 (transcript variant 1) protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- Purity
- > 95 % as determined by SDS-PAGE and Coomassie blue staining
- Endotoxin Level
- < 0.1 EU per μg protein as determined by LAL test
- Top Product
- Discover our top product MAPKSP1 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 20 mM Tris-HCl, 100 mM NaCl, 5 mM DTT, 30 % Glycerol, pH 8.0. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))
- Alternative Name
- Map2k1ip1 (MAPKSP1 Products)
- Synonyms
- MAPKSP1 Protein, MAP2K1IP1 Protein, MAPBP Protein, MP1 Protein, PRO0633 Protein, Ragulator3 Protein, AW556229 Protein, Map2k1ip1 Protein, Mapbp Protein, Mapksp1 Protein, Mp1 Protein, mapksp1 Protein, zgc:110207 Protein, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Protein, LAMTOR3 Protein, Lamtor3 Protein, lamtor3 Protein
- Background
- This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
- Molecular Weight
- 15.8 kDa
- NCBI Accession
- NP_068805
- Pathways
- PI3K-Akt Signaling
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