KNG1 Protein (Transcript Variant 2)
-
- Target See all KNG1 Proteins
- KNG1 (Kininogen 1 (KNG1))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 2
-
Origin
- Human
-
Source
- HEK-293 Cells
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
-
- Recombinant human Kininogen-1 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 95 % as determined by SDS-PAGE and Coomassie blue staining
- Endotoxin Level
- < 0.1 EU per μg protein as determined by LAL test
- Top Product
- Discover our top product KNG1 Protein
-
Kininogen 1 (KNG1) (AA 19-380) protein (His tag)
KNG1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Kininogen 1 (KNG1) (AA 322-427) protein (GST tag)KNG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Kininogen 1 (KNG1) (AA 1-427) protein (GST tag)KNG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Kininogen 1 (KNG1) (Active) protein (His tag)KNG1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
-
- Application Notes
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Restrictions
- For Research Use only
-
- Buffer
- Lyophilized from a 0.2 μM filtered solution of 20 mM Hac-NaAC, 150 mM NaCl, pH 4.0. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- Target
- KNG1 (Kininogen 1 (KNG1))
- Alternative Name
- Kininogen-1 (KNG1 Products)
- Synonyms
- BDK Protein, BK Protein, KNG Protein, Kng Protein, KNG2 Protein, fb64g01 Protein, wu:fb64g01 Protein, zgc:103569 Protein, kininogen Protein, bdk Protein, kng Protein, KNG1 Protein, IHRP Protein, KINKG Protein, KINKH Protein, Kng1 Protein, Kngk Protein, kininogen 1 Protein, kininogen 1 L homeolog Protein, inter-alpha-trypsin inhibitor heavy chain family member 4 Protein, kininogen 2-like 1 Protein, KNG1 Protein, Kng1 Protein, kng1 Protein, kng1.L Protein, ITIH4 Protein, Kng2l1 Protein
- Background
- (1) Kininogens are inhibitors of thiol proteases (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action) (5) LMW-kininogen inhibits the aggregation of thrombocytes (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. [UniProtKB/Swiss-Prot Function]
- Molecular Weight
- 46.9 kDa
- NCBI Accession
- NP_000884
- Pathways
- ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
-
