HGS Protein (Myc-DYKDDDDK Tag)
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- Target See all HGS Proteins
- HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This HGS protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human HGS / HRS protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product HGS Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
- Alternative Name
- Hgs,hrs (HGS Products)
- Synonyms
- HRS Protein, Hrs Protein, fi34f05 Protein, zgc:63492 Protein, wu:fi34f05 Protein, Hgr Protein, ZFYVE8 Protein, CG2903 Protein, Dmel\\CG2903 Protein, HRS-2 Protein, Vps27 Protein, hrs Protein, l(2)23AB5 Protein, l(2)23Ad Protein, l(2)23Ad(Hrs) Protein, vps27 Protein, hgs Protein, hepatocyte growth factor-regulated tyrosine kinase substrate Protein, HGF-regulated tyrosine kinase substrate Protein, Hepatocyte growth factor regulated tyrosine kinase substrate Protein, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog Protein, HGS Protein, Hgs Protein, hgs Protein, Hrs Protein, hgs.L Protein
- Background
- Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. [UniProtKB/Swiss-Prot Function]
- Molecular Weight
- 86 kDa
- NCBI Accession
- NP_004703
- Pathways
- EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation
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