ATF2 Protein (His tag)
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- Target See all ATF2 Proteins
- ATF2 (Activating Transcription Factor 2 (ATF2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ATF2 protein is labelled with His tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human ATF2 (full length, N-term HIS tag) protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product ATF2 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the N-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- ATF2 (Activating Transcription Factor 2 (ATF2))
- Alternative Name
- Atf2 (ATF2 Products)
- Synonyms
- CRE-BP1 Protein, CREB2 Protein, HB16 Protein, TREB7 Protein, CG12850 Protein, CG3749 Protein, dATF-2 Protein, DmelCG30420 Protein, CG30420 Protein, CHN1 Protein, Atf-2 Protein, CRE-BP Protein, Creb2 Protein, D130078H02Rik Protein, D18875 Protein, Tg(Gzma-Klra1)7Wum Protein, mXBP Protein, atf2-A Protein, atf2l Protein, activating transcription factor 2 Protein, Activating transcription factor-2 Protein, activating transcription factor 2 S homeolog Protein, ATF2 Protein, Atf-2 Protein, Atf2 Protein, atf2.S Protein, atf2 Protein
- Background
- This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene
- Molecular Weight
- 54.4 kDa
- NCBI Accession
- NP_001871
- Pathways
- MAPK Signaling, RTK Signaling, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades
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