CDKN1B Protein (DYKDDDDK Tag)
-
- Target See all CDKN1B Proteins
- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
- Protein Type
- Recombinant
-
Origin
- Human
-
Source
- Insect cells (Sf9)
- Purification tag / Conjugate
- This CDKN1B protein is labelled with DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
-
- Recombinant human CDKN1B / KIP1 (full length, C-term DDK tag) protein expressed in Sf9 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CDKN1B Protein
-
-
- Application Notes
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
-
The tag is located at the C-terminal.
- Restrictions
- For Research Use only
-
- Concentration
- 50 μg/mL
- Buffer
- 50 mM Tris-HCl, pH 8.0, 100 mM glycine, 10 % glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- Target
- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
- Alternative Name
- Cdkn1b,kip1 (CDKN1B Products)
- Synonyms
- CDKN4 Protein, KIP1 Protein, MEN1B Protein, MEN4 Protein, P27KIP1 Protein, cdkn1b Protein, sb:cb611 Protein, wu:fb63g10 Protein, wu:fb64g10 Protein, wu:fe18e03 Protein, CDKN1B Protein, Kip1 Protein, p27 Protein, FAM14D Protein, ISG12 Protein, ISG12A Protein, P27 Protein, Cdki1b Protein, AA408329 Protein, AI843786 Protein, p27Kip1 Protein, cdkn1bl Protein, cyclin dependent kinase inhibitor 1B Protein, cyclin-dependent kinase inhibitor 1Bb Protein, interferon alpha inducible protein 27 Protein, cyclin-dependent kinase inhibitor 1B Protein, cyclin-dependent kinase inhibitor 1Ba Protein, CDKN1B Protein, cdkn1bb Protein, IFI27 Protein, Cdkn1b Protein, cdkn1ba Protein
- Background
- This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
- Molecular Weight
- 22.1 kDa
- NCBI Accession
- NP_004055
- Pathways
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
-