Cyclin D2 Protein (CCND2) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2712725

Product Details

Target: Cyclin D2 (CCND2)

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Cyclin D2 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human Cyclin D2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: Cyclin D2 (CCND2)

Alternative Name: Cyclin d2 (CCND2 Products)

Synonyms: si:ch211-240j22.2 Protein, ccnd2 Protein, CCND2 Protein, kiak0002 Protein, zgc:162280 Protein, LOC100224096 Protein, KIAK0002 Protein, BF642806 Protein, C86853 Protein, Vin-1 Protein, Vin1 Protein, cD2 Protein, 2600016F06Rik Protein, AI256817 Protein, cyclin D2, b Protein, cyclin D2 S homeolog Protein, cyclin D2 Protein, G1/S-specific cyclin-D2 Protein, cyclin D2, a Protein, cyclin D2 L homeolog Protein, ccnd2b Protein, ccnd2.S Protein, CCND2 Protein, ccnd2 Protein, ccnd2a Protein, Ccnd2 Protein, ccnd2.L Protein

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).

Molecular Weight: 32.9 kDa

NCBI Accession: NP_001750

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases