NR1H4 Protein (His tag)
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- Target See all NR1H4 Proteins
- NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This NR1H4 protein is labelled with His tag.
- Application
- Protein Interaction (PI)
- Characteristics
- Recombinant FXR is isolated from an E. coli strain that carries the coding sequence of the human FXR under the control of a T7 promoter (accession number U68233). The purified recombinant protein has an amino terminal polyhistidine tag and is greater than 90 % homogeneous and contains no detectable protease, DNase and RNase activity.
- Purity
- The purified recombinant protein has an amino terminal polyhistidine tag and is greater than 90 % homogeneous and contains no detectable protease, DNase and RNase activity.
- Top Product
- Discover our top product NR1H4 Protein
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Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 363-472) protein (GST tag)
NR1H4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 1-476) protein (GST tag)NR1H4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 1-476), (Isoform 3) protein (His-SUMO Tag)NR1H4 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) proteinNR1H4 Origin: Rat Host: Escherichia coli (E. coli) Recombinant WB, SDS, ELISA, IP
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- Application Notes
- Recombinant FXR is suitable for DNA and protein-protein interaction assays. 20 ng is sufficient for gelshift assays and 100 ng is sufficient for protein-protein interaction studies. The molecular weight of the protein is ~55 kDa. NOTE: The presence of Poly [d(I-C)] in buffers may affect protein functionality and should be avoided.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 μg/μL
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- Target
- NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
- Alternative Name
- FXR (NR1H4 Products)
- Synonyms
- zgc:110190 Protein, zgc:92742 Protein, NR1H4 Protein, BAR Protein, FXR Protein, HRR-1 Protein, HRR1 Protein, RIP14 Protein, AI957360 Protein, Fxr Protein, Rxrip14 Protein, nuclear receptor subfamily 1, group H, member 5 S homeolog Protein, nuclear receptor subfamily 1, group H, member 4 Protein, nuclear receptor subfamily 1 group H member 4 Protein, nr1h5.S Protein, nr1h4 Protein, NR1H4 Protein, Nr1h4 Protein
- Background
- The farnesoid X receptor (FXR) or nuclear receptor subfamily 1, group H, member 4 (NR1H4) is a nuclear receptor that, when activated, translocates to the nucleus where it interacts with certain proteins, including RXR and PPARGC1A, forming heterodimers that bind to hormone response elements on DNA and modulate gene expression. One of the primary functions of FXR is to suppress bile acid synthesis when levels are high by inhibiting the transcription of cholesterol 7 alpha-hydroxylase (CYP7A1) gene that expresses CYP7A1, the rate-limiting enzyme in bile acid synthesis from cholesterol.
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process
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