PPIA Protein

Catalog No. ABIN2669342

Product Details

Target: PPIA (Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Western Blotting (WB), SDS-PAGE (SDS)

Purity: >99 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 20 mM Tris pH 8.0, 20 mM NaCl, 0.5 mM DTT, 10 % (v/v) glycerol

Storage: -20 °C

Target Details

Target: PPIA (Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA))

Alternative Name: CyclophilinA (PPIA Products)

Synonyms: Cyp1 Protein, PPIA-2 Protein, fa93g09 Protein, ppia Protein, wu:fa93g09 Protein, wu:fb05e11 Protein, wu:fb13h02 Protein, wu:fb15a05 Protein, CYPA Protein, CypA Protein, Cypa Protein, CYPH Protein, CYCA Protein, CyP-A Protein, MGC75715 Protein, 2700098C05 Protein, Cphn Protein, CyP-18 Protein, MT-ND1 Protein, MTND1 Protein, NADH1 Protein, ND1 Protein, cypA Protein, PPIase A Protein, ppial Protein, wu:fj18g05 Protein, zgc:73102 Protein, zgc:86688 Protein, peptidylprolyl isomerase A Protein, peptidylprolyl isomerase Aa (cyclophilin A) Protein, peptidylprolyl isomerase A (cyclophilin A) L homeolog Protein, cyclophilin A Protein, cyclophilin a Protein, peptidylprolyl isomerase A (cyclophilin A) Protein, peptidylprolyl isomerase Ab (cyclophilin A) Protein, PPIA Protein, ppiaa Protein, ppia.L Protein, Cypa Protein, CNB01230 Protein, CNB01290 Protein, Tc00.1047053506925.300 Protein, Tb11.03.0250 Protein, CYPA Protein, Ppia Protein, ppia Protein, ppiab Protein

Background: Cyclophilin A (CypA, 18 kDa) is the first peptidyl-prolil cis-trans isomerase (PPIase) to be discovered, PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Cyclophilins belong to the superfamily of immunophilins, highly conserved cytoplasmic proteins which share the PPI enzymatic activity and the ability to bind immunosuppressive drugs. CypA binds to and mediates the effect of Cyclosporin A, the CsA/CypA complex selectively binds and inactivates the serine/theronine phosphatase calcineurin leading to disruption of T-cells activating cascade. CsA binding occurs at the active site of the protein thus inhibiting its enzymatic activity. CypA has been demonstrated to be involved in several steps of viral infections such as those mediated by HIV, HBV and HCV.