Lamin A/C Protein (LMNA)
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- Target See all Lamin A/C (LMNA) Proteins
- Lamin A/C (LMNA)
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- Western Blotting (WB), SDS-PAGE (SDS)
- Characteristics
- Recombinant human lamin A is a 645 amino acids protein with a molecular weight of 70 kDa.
- Purity
- > 90 %
- Top Product
- Discover our top product LMNA Protein
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Lamin A/C (LMNA) (AA 1-664) protein (GST tag)
LMNA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Lamin A/C (LMNA) (AA 26-198) protein (His tag)LMNA Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Lamin A/C (LMNA) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)LMNA Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Lamin A/C (LMNA) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)LMNA Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 20 mM phosphate buffer pH 7.0, 0.5M NaCl, 1 mM DTT, 1.5 mM EDTA, 20 % (v/v) glycerol
- Storage
- -20 °C
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- Target
- Lamin A/C (LMNA)
- Alternative Name
- Lamin A (LMNA Products)
- Background
- Lamin A is a major component of the nuclear lamina, a dynamic meshwork located just under the nuclear envelope and it is encoded by lamin A/C gene (LMNA). Lamin A is synthesized as a longer precursor, prelamin A (code REP0038), that in vivo undergoes to serial post-translational modifications that lead to mature lamin A. Different mutations in the LMNA gene have been associated with different diseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familiar partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
- Pathways
- Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
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