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CXCL17 Protein (AA 24-119)

CXCL17 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 98 % , as determined by Coomassie stained SDS-PAGE. FACS Active
Catalog No. ABIN2666918
  • Target See all CXCL17 Proteins
    CXCL17 (Chemokine (C-X-C Motif) Ligand 17 (CXCL17))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 24-119
    Origin
    • 4
    • 4
    • 3
    • 1
    • 1
    Human
    Source
    • 12
    • 1
    Escherichia coli (E. coli)
    Application
    Flow Cytometry (FACS)
    Purity
    > 98 % , as determined by Coomassie stained SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level

    Less than 0.01 ng per μg cytokine as determined by the LAL method.

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  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Biological activity: Bioactivity was measured by its antimicrobial activity (E.coli) in a dose dependent manner.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Reconstitution
    For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 μg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1 % BSA or HSA. After dilution, the cytokine can be stored between 2 °C and 8 °C for one month or from -20 °C to -70 °C for up to 3 months.
    Buffer
    0.22 μm filtered protein solution is in PBS.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    -20 °C
    Storage Comment
    Unopened vial can be stored between 2°C and 8°C for three months, at -20°C for six months, or at -70°C for one year.
  • Target
    CXCL17 (Chemokine (C-X-C Motif) Ligand 17 (CXCL17))
    Alternative Name
    CXCL17 (CXCL17 Products)
    Synonyms
    DMC Protein, Dcip1 Protein, UNQ473 Protein, VCC-1 Protein, VCC1 Protein, Vcc1 Protein, RGD1304717 Protein, C-X-C motif chemokine ligand 17 Protein, chemokine (C-X-C motif) ligand 17 Protein, CXCL17 Protein, Cxcl17 Protein
    Background
    CXCL17 is the latest identified member of the CXC chemokine family and may contribute to tumor angiogenesis and progression. Ectopic expression of human CXCL17 in HUVEC significantly upregulated the RNA level of genes involved in angiogenesis including VEGF-A and basic FGF. NIH3T3 cells overexpressing human or mouse CXCL17 developed rapid growing tumors in mice. In vitro chemotaxis assay shows that human CXCL17 can induce migration of CD14+ monocytes and CD11c+ immature dendritic cells from human peripheral blood, and mouse CXCL17 can induce CD11b+Gr1highF4/80- cells from mouse spleen cells. CXCL17 also shows broad antimicrobial activity by disrupting bacterial membrane. High levels of CXCL17 have been detected in bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis.
    Molecular Weight
    The 96 amino acid recombinant protein has a predicted molecular mass of approximately 11.3 kDa. The DTT-reduced protein migrates at approximately 11.3 kDa and non-reduced protein migrates at approximately 24 kDa by SDS-PAGE. The N-terminal amino acid is L
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