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BMP5 Protein (AA 317-454)

BMP5 Origin: Human Host: CHO Cells Recombinant > 95 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis. MA Active
Catalog No. ABIN2666463
  • Target See all BMP5 Proteins
    BMP5 (Bone Morphogenetic Protein 5 (BMP5))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 317-454
    Origin
    • 8
    • 3
    Human
    Source
    • 5
    • 5
    • 1
    CHO Cells
    Application
    Multiplex Assay (MA)
    Purity
    > 95 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
    Endotoxin Level

    Less than 0.1 ng per μg of protein.

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    Discover our top product BMP5 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Biological activity: BMP-5 induces alkaline phosphatase production on ATDC-5 cells. The expected ED50 = 0.5 - 1.0 μg/ml, corresponding to a specific activity of 1.0 - 2.0 x 103 unit/mg.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer containing a carrier protein such as 0.1 % BSA and store working aliquots at -20 °C to -80 °C.
    Buffer
    Lyophilized
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    -20 °C
    Storage Comment
    Unopened vial can be stored at -20°C or -70°C.
  • Target
    BMP5 (Bone Morphogenetic Protein 5 (BMP5))
    Alternative Name
    BMP-5 (BMP5 Products)
    Synonyms
    bmp5l Protein, hm:zehl0669 Protein, zehl0669 Protein, zgc:64230 Protein, BMP5 Protein, AU023399 Protein, se Protein, bone morphogenetic protein 5 Protein, bmp5 Protein, BMP5 Protein, LOC100539495 Protein, Bmp5 Protein
    Background
    Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGF-β) superfamily. BMPs play a key role in embryonic development, especially during heart, neural, and cartilage development. Around 20 BMP family members have been identified and characterized. BMPs signal through serine/threonine kinase receptors, composed of type I and II subtypes. Four type I receptors have been identified: type IA and IB BMP receptors, type IA activin receptor, and activin receptor-like kinase I. Three type II receptors have also been recognized: type II BMP receptor and type II and IIB activin receptors. Nervous system development involves several BMPs including BMP-2, 4, 5, and 7. BMP-5 is widely expressed in the nervous system throughout development and into adulthood, and BMP-5 induces multiple dendritic processes to sympathetic neurons in culture. BMP-5 plays an important role in fracture healing during the stage of cartilage formation and periosteal response. In addition, BMP-4 and BMP-5 are expressed in normal synovial tissue and have been found to be decreased in osteoarthritis and rheumatoid arthritis, therefore, it has been speculated that these BMPs are important in joint homeostasis.
    Molecular Weight
    The 138 amino acid recombinant protein has a predicted molecular mass of approximately 15.6 kDa. Recombinant human BMP-5 is a homodimeric disulfide-linked protein. The predicted N-terminal amino acid is Ala.
    Pathways
    Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process
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