Thrombomodulin Protein (THBD)
THBD
Origin: Human
Host: HEK-293 Cells
Recombinant
<= 98 % by SDS-PAGE gel and HPLC analyses.
Active
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- Target See all Thrombomodulin (THBD) Proteins
- Thrombomodulin (THBD)
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- HEK-293 Cells
- Sequence
- APAEPQPGGS QCVEHDCFAL YPGPATFLNA SQICDGLRGH LMTVRSSVAA DVISLLLNGD GGVGRRRLWI GLQLPPGCGD PKRLGPLRGF QWVTGDNNTS YSRWARLDLN GAPLCGPLCV AVSAAEATVP SEPIWEEQQC EVKADGFLCE FHFPATCRPL AVEPGAAAAA VSITYGTPFA ARGADFQALP VGSSAAVAPL GLQLMCTAPP GAVQGHWARE APGAWDCSVE NGGCEHACNA IPGAPRCQCP AGAALQADGR SCTASATQSC NDLCEHFCVP NPDQPGSYSC MCETGYRLAA DQHRCEDVDD CILEPSPCPQ RCVNTQGGFE CHCYPNYDLV DGECVEPVDP CFRANCEYQC QPLNQTSYLC VCAEGFAPIP HEPHRCQMFC NQTACPADCD PNTQASCECP EGYILDDGFI CTDIDECENG GFCSGVCHNL PGTFECICGP DSALARHIGT DCDSGKVDGG DSGSGEPPPS PTPGSTLTPP A
- Characteristics
- Biological activity was measured by its ability to activate protein C induced cleavage of the chromogenic substrate, BOC-Asp-Pro Arg-AMC in the presence of thrombin. The specific activity is greater than 500 pmoles/min/μg.
- Purity
- <= 98 % by SDS-PAGE gel and HPLC analyses.
- Endotoxin Level
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
- Top Product
- Discover our top product THBD Protein
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Thrombomodulin (THBD) protein (His tag)
THBD Origin: Mouse Host: Human Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
Thrombomodulin (THBD) protein (His tag)THBD Origin: Rat Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Handling Advice
- As with any protein, exposing Thrombomodulin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Storage
- -20 °C
- Storage Comment
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Thrombomodulin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
- Expiry Date
- 24 months
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- Target
- Thrombomodulin (THBD)
- Alternative Name
- Thrombomodulin (THBD Products)
- Synonyms
- AHUS6 Protein, BDCA3 Protein, CD141 Protein, THPH12 Protein, THRM Protein, TM Protein, AI385582 Protein, THBD Protein, HAST Protein, HAST3 Protein, M-PST Protein, ST1A3/ST1A4 Protein, ST1A5 Protein, STM Protein, TL-PST Protein, thrombomodulin Protein, sulfotransferase family 1A member 3 Protein, THBD Protein, Thbd Protein, SULT1A3 Protein
- Background
- Thrombomodulin (TM, CD141, THBD) is an endothelial cell expressed transmembrane glycoprotein that can form a complex with the coagulation factor, Thrombin. The Thrombomodulin/Thrombin complex converts protein C to its activated form, protein Ca, which in turn proteolytically cleaves and deactivates factor Va and factor VIIIa, two essential components of the coagulation mechanism. This inactivation reduces the generation of additional thrombin and thereby effectively prevents continued coagulation. Reduced levels of Thrombomodulin can correlate with the pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. However, the serum levels of the truncated circulating form of Thrombomodulin are typically elevated during inflammation and in the presence of various inflammatory related diseases. Recombinant soluble Thrombomodulin is a 491 amino acid glycoprotein containing the extracellular domain of Thrombomodulin.
- Gene ID
- 7056
- NCBI Accession
- NP_000352
- OMIM
- 4507483
- UniProt
- P07204
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