Calreticulin Protein (CALR) (AA 18-417)
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- Target See all Calreticulin (CALR) Proteins
- Calreticulin (CALR)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 18-417
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- Western Blotting (WB), ELISA, Mass Spectrometry (MS)
- Purity
- ~90 %
- Top Product
- Discover our top product CALR Protein
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Calreticulin (CALR) protein (His tag)
CALR Origin: Human Host: Escherichia coli (E. coli) Recombinant >90 % (SDS-PAGE) SDS
Calreticulin (CALR) (AA 25-199) protein (His-IF2DI Tag)CALR Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Calreticulin (CALR) (AA 1-417) protein (GST tag)CALR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Calreticulin (CALR) (AA 18-417) protein (His tag)CALR Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
Calreticulin (CALR) (AA 18-417) protein (His tag)CALR Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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- Application Notes
- This recombinant protein can be used for WB, ELISA, MS.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 10 mM Tris, pH 8.0, 0.002 % NaN, 3 mM NaCl, 2.5 mM
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Storage
- -80 °C
- Storage Comment
- Store in working aliquots at -70 °C.
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- Target
- Calreticulin (CALR)
- Alternative Name
- CALR (CALR Products)
- Background
- Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.
- Molecular Weight
- 46 kDa (Calculated)
- Gene ID
- 811
- NCBI Accession
- NP_004334
- OMIM
- 4757900
- UniProt
- P27797
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response
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