BMP5 Protein

Catalog No. ABIN2468294

Product Details

Target: BMP5 (Bone Morphogenetic Protein 5 (BMP5))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: CHO Cells

Sequence: AANKRKNQNR NKSSSHQDSS RMSSVGDYNT SEQKQACKKH ELYVSFRDLG WQDWIIAPEG YAAFYCDGEC SFPLNAHMNA TNHAIVQTLV HLMFPDHVPK PCCAPTKLNA ISVLYFDDSS NVILKKYRNM VVRSCGCH

Characteristics: Biological activity was determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 1.0-2.0 μg/mL.

Purity: < 95 % by SDS-PAGE gel and HPLC analyses.

Endotoxin Level: Endotoxin level is less than 0.1 ng per μg (1 EU/μg).

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Handling Advice: As with any protein, exposing BMP-5 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Storage: -20 °C

Storage Comment: The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted BMP-5 stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.

Expiry Date: 24 months

Target Details

Target: BMP5 (Bone Morphogenetic Protein 5 (BMP5))

Alternative Name: BMP-5 (BMP5 Products)

Synonyms: bmp5l Protein, hm:zehl0669 Protein, zehl0669 Protein, zgc:64230 Protein, BMP5 Protein, AU023399 Protein, se Protein, bone morphogenetic protein 5 Protein, bmp5 Protein, BMP5 Protein, LOC100539495 Protein, Bmp5 Protein

Background: TGF-beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-5 is expressed in the nervous system, lung and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein. Recombinant human BMP-5 is a 31.2 kDa homodimeric disulfide-linked protein consisting of two identical 138 amino acid chains.

Gene ID: 653

NCBI Accession: NP_066551

OMIM: 10835091

UniProt: P22003

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process