PCSK9 Protein (AA 31-692) (His tag)
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- Target See all PCSK9 Proteins
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 31-692
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This PCSK9 protein is labelled with His tag.
- Sequence
- AA 31-692
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 75.1 kDa. The protein migrates as 20 kDa and 62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation and proteolytic digestion.
- Purity
- >97 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product PCSK9 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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PCSK9 Activity Is Potentiated Through HDL Binding." in: Circulation research, (2021) (PubMed).
: "Evolution of sequence-defined highly functionalized nucleic acid polymers." in: Nature chemistry, Vol. 10, Issue 4, pp. 420-427, (2019) (PubMed).
: "Side chain determinants of biopolymer function during selection and replication." in: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).
: "The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance." in: JCI insight, Vol. 4, Issue 11, (2019) (PubMed).
: "Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor." in: Scientific reports, Vol. 8, Issue 1, pp. 10496, (2018) (PubMed).
: "Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia." in: Acta diabetologica, Vol. 54, Issue 2, pp. 191-199, (2017) (PubMed).
: "The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA." in: The Journal of biological chemistry, Vol. 292, Issue 5, pp. 1573-1590, (2017) (PubMed).
: "Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor." in: PLoS ONE, Vol. 11, Issue 5, pp. e0155030, (2017) (PubMed).
: "Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis." in: Journal of innate immunity, Vol. 8, Issue 2, pp. 211-20, (2016) (PubMed).
: "PCSK9 is a critical regulator of the innate immune response and septic shock outcome." in: Science translational medicine, Vol. 6, Issue 258, pp. 258ra143, (2015) (PubMed).
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PCSK9 Activity Is Potentiated Through HDL Binding." in: Circulation research, (2021) (PubMed).
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- Target
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- Alternative Name
- PCSK9 (PCSK9 Products)
- Synonyms
- FH3 Protein, HCHOLA3 Protein, LDLCQ1 Protein, NARC-1 Protein, NARC1 Protein, PC9 Protein, AI415265 Protein, AI747682 Protein, Narc1 Protein, proprotein convertase subtilisin/kexin type 9 Protein, proprotein convertase subtilisin/kexin type 9 L homeolog Protein, PCSK9 Protein, pcsk9.L Protein, pcsk9 Protein, Pcsk9 Protein
- Background
- Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
- Molecular Weight
- 13.8 kDa and 58.1 kDa
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