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FLT3LG Protein (AA 27-185)

FLT3LG Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Catalog No. ABIN2181107
  • Target See all FLT3LG Proteins
    FLT3LG (Fms-Related tyrosine Kinase 3 Ligand (FLT3LG))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 27-185
    Origin
    • 22
    • 14
    • 2
    • 1
    Human
    Source
    • 13
    • 10
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    HEK-293 Cells
    Brand
    ActiveMax®
    Sequence
    AA 27-185
    Characteristics
    This protein carries no "tag". The protein has a calculated MW of 18.9 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE).
    Purity
    >95 % as determined by SDS-PAGE.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product FLT3LG Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    FLT3LG (Fms-Related tyrosine Kinase 3 Ligand (FLT3LG))
    Alternative Name
    Flt-3 Ligand (FLT3LG Products)
    Synonyms
    Flt3lg Protein, Ly72L Protein, FL Protein, FLT3L Protein, Vegfr3 Protein, fms related tyrosine kinase 3 ligand Protein, FMS-like tyrosine kinase 3 ligand Protein, fms-related tyrosine kinase 4 Protein, fms-related tyrosine kinase 3 ligand Protein, FLT3LG Protein, Flt3l Protein, Flt4 Protein, Flt3lg Protein
    Background
    FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.
    Molecular Weight
    18.0 kDa
    Pathways
    RTK Signaling
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