BMP2 Protein (AA 284-396)

Catalog No. ABIN2180654

This Recombinant BMP2 protein is produced in Escherichia coli (E. coli).

Quick Overview for BMP2 Protein (AA 284-396) (ABIN2180654)

Target: BMP2 (Bone Morphogenetic Protein 2 (BMP2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: >92 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 284-396

Sequence: AA 284-396

Characteristics: This protein carries no "tag". The protein has a calculated MW of 13 kDa. the protein migrates as 13 kDa under reducing (R) condition, and 24 kDa under non-reducing (NR) condition (SDS-PAGE).

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 100 mM Acetic Acid, pH 2.8

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Target Details

Target: BMP2 (Bone Morphogenetic Protein 2 (BMP2))

Alternative Name: BMP-2

Background: Human bone morphogenetic protein 2 (BMP2) is also known as human BMP-2, BMP-2, BMP2, BMP 2, h-BMP-2, rh-BMP-2, recombinant human BMP-2, recombinant BMP-2, BMP, is a member of the BMP subgroup belonging to the TGF-b superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. As implied by its name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function.

Molecular Weight: 12.8 kDa

NCBI Accession: NP_001191

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Growth Factor Binding, Positive Regulation of fat Cell Differentiation