ITM2B Protein (AA 76-266) (His tag)
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- Target See all ITM2B Proteins
- ITM2B (Integral Membrane Protein 2B (ITM2B))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 76-266
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This ITM2B protein is labelled with His tag.
- Purpose
- Recombinant Human Integral Membrane Protein 2B/ITM2B/imBRI2 (C-6His)
- Sequence
- YKYFALQPDD VYYCGIKYIK DDVILNEPSA DAPAALYQTI EENIKIFEEE EVEFISVPVP EFADSDPANI VHDFNKKLTA YLDLNLDKCY VIPLNTSIVM PPRNLLELLI NIKAGTYLPQ SYLIHEHMVI TDRIENIDHL GFFIYRLCHD KETYKLQRRE TIKGIQKREA SNCFAIRHFE NKFAVETLIC SVDHHHHHH
- Characteristics
- Recombinant Human Integral Membrane Protein 2B/ITM2B is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Tyr76-Ser266) of Human ITM2B fused with a polyhistidine tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product ITM2B Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- ITM2B (Integral Membrane Protein 2B (ITM2B))
- Alternative Name
- ITM2B (ITM2B Products)
- Synonyms
- ABRI Protein, BRI Protein, BRI2 Protein, BRICD2B Protein, E25B Protein, E3-16 Protein, FBD Protein, imBRI2 Protein, AI256040 Protein, Bri Protein, Bri2 Protein, Bricd2b Protein, D14Sel6 Protein, E25BMM Protein, itm2b Protein, zgc:55770 Protein, zgc:85688 Protein, wu:fc05f02 Protein, MGC52745 Protein, MGC76131 Protein, ITM2B Protein, itm2bl Protein, wu:fb94b03 Protein, zgc:64142 Protein, integral membrane protein 2B Protein, integral membrane protein 2Ba Protein, integral membrane protein 2B L homeolog Protein, integral membrane protein 2b Protein, integral membrane protein 2Bb Protein, ITM2B Protein, Itm2b Protein, itm2ba Protein, itm2b.L Protein, itm2b Protein, itm2bb Protein
- Background
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Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. CAA-ITM2B2 characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.
Synonyms: Integral Membrane Protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane Protein BRI, Bri, ITM2B, BRI, BRI2 - Molecular Weight
- 23.3 kDa
- UniProt
- Q9Y287
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