NRG1-beta 1 Protein (AA 1-246) (His tag)
NRG1-beta 1
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 95 % as determined by reducing SDS-PAGE.
-
- Target See all NRG1-beta 1 products
- NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-246
- Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This NRG1-beta 1 protein is labelled with His tag.
- Purpose
- Recombinant Human Pro-Neuregulin-1/NRG1-β1/HRG1-β1 (Met1-Lys246, N-6His)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPQLK EMKSQESAAG SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KHLGIEFMEA EELYQK
- Characteristics
- Recombinant Human Pro-neuregulin-1 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Lys246) of Human NRG1.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
-
Neuregulin-1 beta 1 (NRG1-beta 1) (AA 2-246) (Active) protein (Fc Tag)
NRG1-beta 1 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
-
It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of 4 mM HCl.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- 4 °C/-20 °C/-80 °C
- Storage Comment
-
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- Target
- NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))
- Abstract
- NRG1-beta 1 Products
- Background
-
Neuregulin-1 (heregulin-1,NRG1) is a member of neuregulin family, which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.
Synonyms: Pro-neuregulin-1,Neuregulin-1 beta 1,NRG1-beta 1,HRG1-beta 1 ECD,EGF,NRG1, GGF, HGL, HRGA, NDF, SMDF, - Molecular Weight
- 29 kDa
-
You are here:
