TGFA Protein (AA 40-89)
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- Target See all TGFA Proteins
- TGFA (Transforming Growth Factor, alpha (TGFA))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 40-89
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Origin
- Human
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Source
- CHO Cells
- Characteristics
- ED50 < 0.4 ng/mL, measured in a cell proliferation assay using 3T3 cells.
- Purity
- > 95 % as analyzed by SDS-PAGE and HPLC.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product TGFA Protein
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Transforming Growth Factor, alpha (TGFA) (AA 40-89) protein (Fc Tag)
TGFA Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Transforming Growth Factor, alpha (TGFA) (AA 39-88) protein (Fc Tag)TGFA Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Transforming Growth Factor, alpha (TGFA) (AA 40-89) protein (His tag)TGFA Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Transforming Growth Factor, alpha (TGFA) (AA 1-159) protein (GST tag)TGFA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Transforming Growth Factor, alpha (TGFA) (AA 42-89) protein (GST tag)TGFA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant Human TGF-alpha remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human TGF-alpha Receptor should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- TGFA (Transforming Growth Factor, alpha (TGFA))
- Alternative Name
- Transforming Growth Factor-alpha (TGF-Alpha) (TGFA Products)
- Synonyms
- TFGA Protein, LOC100009482 Protein, TGF alpha Protein, TGFA Protein, wa-1 Protein, wa1 Protein, RATTGFAA Protein, TGFAA Protein, NV15606 Protein, si:ch211-10e8.7 Protein, transforming growth factor alpha Protein, transforming growth factor alpha L homeolog Protein, transforming growth factor-alpha Protein, transforming growth factor, alpha Protein, TGFA Protein, TGF-A Protein, Tgfa Protein, tgfa.L Protein, LOC100121300 Protein, LOC100009150 Protein, tgfa Protein
- Background
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Protransforming Growth Factor-alpha (TGF-alpha), also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. It is expressed in monocytes, brain cells, keratinocytes and various tumor cells. ProTGF-alpha signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells. It may function as either a membrane-bound ligand or a soluble ligand. Membrane-bound proTGF-alpha plays a role in cell-cell adhesion and juxtacrine stimulation of adjacent cells. The soluble form of the cytokine is released from the membrane-bound form by proteolytic cleavage and acts as a mitogen for cell proliferation.
Synonyms: Transforming Growth Factor-alpha, Sacroma growth factor, TGF-type I, ETGF - Molecular Weight
- 8-10 kDa, observed by reducing SDS-PAGE.
- UniProt
- P01135
- Pathways
- NF-kappaB Signaling, RTK Signaling, EGFR Signaling Pathway
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