beta-Thromboglobulin Protein (beta-TG) (AA 46-107)

Catalog No. ABIN2018402

Product Details

Target: beta-Thromboglobulin (beta-TG)

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 46-107

Origin: Rat

Source: CHO Cells

Characteristics: The EC50 value of rat Thymus Chemokine-1/CXCL7 on Ca2+ mobilization assay in CHO-K1/G alpha 15/rCXCR2 cells (human G alpha 15 and rat CXCR2 stably expressed in CHO-K1 cells) is less than 300 ng/mL.

Purity: > 97 % as analyzed by SDS-PAGE and HPLC.

Endotoxin Level: < 0.2 EU/μg, determined by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Storage: -80 °C

Storage Comment: Lyophilized recombinant Rat Thymus Chemokine-1/CXCL7 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Rat Thymus Chemokine-1/CXCL7 should be stable up to 1 week at 4 °C or up to 3 months at -20 °C.

Expiry Date: 6 months

Target Details

Target: beta-Thromboglobulin (beta-TG)

Abstract: beta-TG Products

Synonyms: B-TG1 Protein, Beta-TG Protein, CTAP-III Protein, CTAP3 Protein, CTAPIII Protein, CXCL7 Protein, LA-PF4 Protein, LDGF Protein, MDGF Protein, NAP-2 Protein, PBP Protein, SCYB7 Protein, TC1 Protein, TC2 Protein, TGB Protein, TGB1 Protein, THBGB Protein, THBGB1 Protein, CTAPIII/NAP-2 Protein, 2400003M24Rik Protein, AI854500 Protein, Cxcl7 Protein, NAP-2-L1 Protein, Scyb7 Protein, b-TG1 Protein, beta-TG Protein, Nap-2 Protein, pro-platelet basic protein Protein, PPBP Protein, Ppbp Protein

Background: Thymus Chemokine-1, also called Chemokine (C-X-C motif) ligand 7 (CXCL7) , is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, Thymus Chemokine-1 has been shown to bind CXCR-2 and be a chemoattractant forneutrophils and play a role in their activation. Although CTAP-III, beta-TG and PBP represent amino-terminal extended variants of Thymus Chemokine-1 and possess the same CXC chemokine domains, these proteins do not exhibit Thymus Chemokine-1 activity. Recently, it has been shown that the additional amino-terminal residues of CTAP-III mask the critical ELR receptor binding domain that is exposed on Thymus Chemokine-1 and may account for lack of Thymus Chemokine-1 activity. Rat CXCL7 shares 72 % amino acid sequence identity with mouse CXCL7.Recombinant rat Thymus Chemokine-1/ CXCL7 produced in CHO cells is a polypeptide chain containing 62 amino acids. A fully biologically active molecule, rrThymus Chemokine-1/CXCL7 has a molecular mass of 9.8 kDa analyzed by reducing SDS-PAGE.
Synonyms: Thymus Chemokine-1,TCK-1

Molecular Weight: 9.8 kDa, observed by reducing SDS-PAGE.

UniProt: Q99ME0