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Oncostatin M Protein (OSM) (AA 26-239)

OSM Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
Catalog No. ABIN2018303
  • Target See all Oncostatin M (OSM) Proteins
    Oncostatin M (OSM)
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 26-239
    Origin
    • 24
    • 5
    • 3
    • 3
    • 1
    • 1
    Rat
    Source
    • 19
    • 12
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Characteristics
    ED50 < 10 ng/mL, measured by a cell proliferation assay using Rat Embryo Brain cells, corresponding to a specific activity of > 1x 10^5 units/mg.
    AA 26-239, expressed with an N-terminal Met.
    Purity
    > 95 % as analyzed by SDS-PAGE and HPLC.
    Endotoxin Level
    < 0.2 EU/μg, determined by LAL method.
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    Discover our top product OSM Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O or PBS at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Storage
    -80 °C
    Storage Comment
    Lyophilized recombinant Rat Oncostatin M (rrOSM) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rrOSM remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    Expiry Date
    6 months
  • Target
    Oncostatin M (OSM)
    Alternative Name
    Oncostatin M(OSM) (OSM Products)
    Synonyms
    OSM Protein, OncoM Protein, oncostatin M Protein, OSM Protein, Osm Protein
    Background
    Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor beta or LIF Receptor beta to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant Mouse Oncostatin M (rmOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 182 amino acids. A fully biologically active molecule, rmOSM has a molecular mass of 20.5 kDa analyzed by reducing SDS-PAGE.
    Synonyms: OSM
    Molecular Weight
    24.5 kDa, observed by reducing SDS-PAGE.
    UniProt
    Q65Z15
    Pathways
    JAK-STAT Signaling, Negative Regulation of Hormone Secretion
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