NOG Protein (AA 28-232)

Catalog No. ABIN2018291

Product Details

Target: NOG (Noggin (NOG))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 28-232

Origin: Human

Source: CHO Cells

Characteristics: ED50<2.5 ng/mL, measured in a bioassay using ATDC5 cells in the presence of 10 ng/mL human BMP-4.

Purity: > 95 % as analyzed by SDS-PAGE.

Endotoxin Level: < 0.2 EU/μg, determined by LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Storage: -80 °C

Storage Comment: Lyophilized recombinant human Noggin remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human Nogginshould be stable up to 1 week at 4°C or up to 2 months at -20°C.

Expiry Date: 6 months

Target Details

Target: NOG (Noggin (NOG))

Alternative Name: Noggin (NOG Products)

Synonyms: SYM1 Protein, SYNS1 Protein, nog-A Protein, nog1 Protein, noggin-1 Protein, noggin Protein, noggin Protein, noggin L homeolog Protein, noggin protein Protein, NOG Protein, Nog Protein, nog.L Protein, noggin Protein

Background: Noggin, also known as NOG, is a homodimeric glycoprotein that bindsto and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors. Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients, regulating cellular responses dependent on the local concentration of the signaling molecule.
Synonyms: NOG

Molecular Weight: 29-31kDa, observed by reducing SDS-PAGE.

UniProt: Q13253

Pathways: Stem Cell Maintenance, Tube Formation